Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted under GLP conditions using methodology that is well accepted by organization responsible for fluorochemicals

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Cardiac sensitization was considered to have occurred if the response to epinephrine was enhanced following administration of the test article.

GLP compliance:
yes

Test material

Results and discussion

Any other information on results incl. tables

All animals survived to study termination. There were no test article-related clinical observations. Body weights were unaffected by test article administration. No cardiac sensitization was observed in any animal.

Applicant's summary and conclusion

Conclusions:
Cardiac sensitization to epinephrine was not observed in dogs exposed by inhalation to the test substance up to to a level of 120000 ppm (559200 mg/m3; highest dose tested).