Registration Dossier
Registration Dossier
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EC number: 271-089-3 | CAS number: 68515-47-9
Endpoint summary
Administrative data
Description of key information
Additional information
DTDP has a low potential to bioaccumulate in the environment based on results from a calculated bioconcentration factor value, a fish dietary lab study with on biomagnifications, results from analogs in a bioaccumulation food-web field study, and a measured biota-soil accumulation factor (BSAF) for a soil-dwelling invertebrate.
Conclusion: Potential of DTDP to bioaccumulate is low.
I5 Summary:
Biomagnification:High molecular weight phthalate esters (di-C8 PEs to di-C10 PEs) have been shown not to biomagnify through the food web, but rather decrease in tissue concentration with increasing trophic position. The results of a study to assess the bioaccumulation of high molecular weight phthalate diesters in an aquatic food-web that included 18 marine species, showed that DIDP did not biomagnify, but rather decreased in tissue concentration in organisms of increasing trophic position. Decreasing concentrations, also referred to as biodilution, can be quantified by food-web magnification factors (FWMFs). A FWMF that is greater than 1.0 is an indication of chemical biomagnification within a food-web, whereas a value of less than 1.0 indicates biodilution or dilution from lower to higher trophic levels. Study results showed that lipid equivalent concentrations of the high molecular weight phthalate diesters significantly declined with increasing trophic level and that the FWMF for di-isodecyl phthalate was 0.44. Similar results would be expected with DTDP, an analog of DIDP.
Biomagnification:The finding above is consistent with a laboratory fish bioaccumulation study in which rainbow trout were fed a DTDP spiked diet for 9 days. The low water solubility and high Kow of DTDP prevent conducting an aqueous exposure BCF (bioconcentration factor) study. At the end of the exposure period, fish were sampled after different depuration times (0, 1, 3 days). Results demonstrated limited bioaccumulation with a lipid normalized biomagnification factor (BMF, concentration ratio in tissue to that in diet) of 0.004 and rapid subsequent depuration with a tissue elimination half-life of less than 1 day. The half-life of 1 day was used to calculate a BCF in fish of 1 L/kg for DTDP.
Bioconcentration:Calculated BCF data for di-isotridecyl phthalate (DTDP) suggest that it has a low potential to bioconcentrate in the aquatic environment.
BSAF:Data to assess the potential for terrestrial bioaccumulation of DIDP were reported in a 14-day earthworm (Eisenia fetida) toxicity study. The biota-soil accumulation factor (BSAF) as measured in a natural soil was 0.015 based on a DIDP concentration in the earthworm of 120 mg/kg (wet weight) and in soil of 7829 mg/kg (dry weight). A BSAF value of 1 indicates a lack of bioaccumulation. Similar results would be expected with DTDP, an analog of DIDP.
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