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EC number: 262-967-7 | CAS number: 61788-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant study, available as unpublished report, no restrictions, adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Terphenyl, hydrogenated
- EC Number:
- 262-967-7
- EC Name:
- Terphenyl, hydrogenated
- Cas Number:
- 61788-32-7
- Molecular formula:
- C18Hn (n >18-36)
- IUPAC Name:
- Terphenyl, hydrogenated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories
- Age at study initiation: Approximately 5 weeks
- Weight at study initiation: 127-185 grams (males), 101-141 grams (females)
- Housing: Individually housed (during the exposure)
- Diet (e.g. ad libitum): ad libitum (except during the exposure period)
- Water (e.g. ad libitum): ad libitum (except during the exposure period)
- Acclimation period: Test animals were held and observed in quarantine for 10 days prior to release for study.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 70-74°F
- Humidity (%): 39-70% relative humidity
- Air changes (per hr): 19.2 to 22.2 liters/min
- Photoperiod: 12 hrs dark / 12 hrs light cycle
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Laskin-type nebulizer
- Exposure chamber volume: 0.3 m³
- Method of holding animals in test chamber: One par cage, positioned in two tiers in the chamber
- Method of particle size determination: Andersen cascade impactor
TEST ATMOSPHERE
- Brief description of analytical method used: Determinated by gas chromatography
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: 92.9-95.8% of particles were less than 10um in size
- MMAD (Mass median aerodynamic diameter): 1.82-2.36um
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas chromatography
- Duration of exposure:
- 4 h
- Remarks on duration:
- single exposure
- Concentrations:
- 2.5 mg/L; 3.6 mg/L; 4.4 mg/L; 4.7 mg/L
- No. of animals per sex per dose:
- 6 Males ,6 Females /exposure concentration
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice daily
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic examination of the external appearance and of tissues of the thoracic, abdominal and cranial cavities.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.7 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- At 4.7 mg/L: 5 rats died (1 males, 4 females) on a total of 36 animals
- Clinical signs:
- other: In treated animals immediately after exposure were observed: salivation increase; wet fur on the ventral side (due to salivation); discharge and/or encrustation about the nose and eyes; labored breathing; prostrate condition and fur coated with test mater
- Body weight:
- At 3.6-4.7 mg/L: decreases in mean body weights.
- Gross pathology:
- Not test-related
- Other findings:
- All of the effects noted above were reversible by the end of the study (day 14)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- LC50 > 4.7 mg/L
- Executive summary:
Six groups of 6 male and 6 female Sprague-Dawley rats per group were each exposed once for 4 hours to atmospheres of aerosolized hydrogenated terphenyl. Mean exposure concentrations ranged from 2,5 to 4.7 mg of Terphenyl, hydrogenated vapor/aerosol per liter of air. The chamber atmospheres were run at elevated and ambient temperatures. Two groups of rats were exposed to house-conditioned air and served as ambient and heated control groups. Exposures were followed by a 14-day observation period and subsequent necropsy. The LC50 for the material could not be calculated due to the low incidence of mortality (3 out of 12 in a single exposure at 4.7 mg/L). In treated animals immediately after exposure, notable observations included salivation, wet fur on the ventral side (due to salivation), discharges and/or encrustation about the nose and eyes, labored breathing, prostrate condition and fur coated with test material. Post-exposure observations included red encrustation about eyes and nose, fur coated with test material and labored breathing. By post-exposure day 14 all surviving animals were in apparent good health. Decreases in mean body weights were noted by post-exposure day 2 in all groups except in the lowest exposure concentration (ambient) and control groups. By the end of the 14 day post-exposure period all groups had exceeded their pre-exposure weights. There were no terminal necropsy findings which are considered to be related to the test material. Based on the test exposure results, the LC50 value for Terphenyl, hydrogenated administered in the study is considered to be greater than 4.7 mg/L.
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