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Diss Factsheets
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EC number: 203-614-9 | CAS number: 108-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No data on GLP and OECD guidelines compliance
Data source
Reference
- Reference Type:
- publication
- Title:
- Cyanuric Chloride Has No Genotoxic and Mutagenic Properties in Bacteria and Bone Marrow Cells
- Author:
- Wyszynska K, Przybojewska B, Spiechowicz E, Chwialkowska-Liro W, Dziubaltowska E, Rydzynski K
- Year:
- 1 994
- Bibliographic source:
- International Journal of Occupational Medicine and Environmental Health, Vol. 7, No. 3, pages 281-289, 1994
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Type of assay:
- other: sister chromatid exchanges (SCEs) and polychromatic erythrocyte (PCE) micronuclei.
Test material
- Reference substance name:
- 2,4,6-trichloro-1,3,5-triazine
- EC Number:
- 203-614-9
- EC Name:
- 2,4,6-trichloro-1,3,5-triazine
- Cas Number:
- 108-77-0
- Molecular formula:
- C3Cl3N3
- IUPAC Name:
- 2,4,6-trichloro-1,3,5-triazine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Frequency of treatment:
- One injection
- Post exposure period:
- 23, 30, or 72 hours after dosing the animals were killed.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
up to 32mg/kg
Basis:
nominal conc.
- Control animals:
- not specified
Examinations
- Tissues and cell types examined:
- The bone marrow was flushed out and scored for sister chromatid exchanges (SCEs) or polychromatic erythrocyte (PCE) micronuclei. . The PCE/normochromatic erythrocyte (NCE) ratios were determined.
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Additional information on results:
- Cyanuric-chloride did not induce SCEs or micronucleated PCEs at any time point in mice. The PCE/NCE ratio was significantly decreased at all sampling times.
Cyanuric-chloride has not demonstrated genotoxicity in murine bone marrow SCE and PCE micronuclei assays. The significant decrease in PCE/NCE ratio in the micronucleus assay may indicate a possible cytostatic effect.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
No genotoxic - Executive summary:
The genotoxic properties of cyanuric-chloride were studied in-vivo. Male and female mice were injected intraperitoneally with up to 32mg/kg cyanuric-chloride. Mice were killed 23, 30 or 72 hours later and the femurs were removed. The bone marrow was flushed out and scored for sister chromatid exchanges (SCEs) or for polychromatic erythrocyte (PCE) micronuclei. The PCE/normochromatic erythrocyte (NCE) ratios were determined. Cyanuric-chloride did not induce SCEs or micronucleated PCEs at any time point in mice. The PCE/NCE ratio was significantly decreased at all sampling times. The authors conclude that cyanuric-chloride has not demonstrated genotoxicity in murine bone marrow SCE and PCE micronuclei assays. The significant decrease in PCE/NCE ratio in the micronucleus assay may indicate a possible cytostatic effect.
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