p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline

Endpoint summary

Description of key information

The half life in water has been determined to be 10.8 days according to the DT50 values taken from OECD 309 Aerobic Mineralisation testing in surface water. After 59 days, the degraded to 8 major unidentified degradates; polar material and unknowns. Tentative identification of four hyrolysis products and their oxidised forms was made.

Additional information

Hydrolysis of p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline was studied at 20, 40 and 50 ºC in sterile aqueous buffered solutions at pH 4, pH 7 and pH 9.  The hydrolysis at 25oC was estimated based on the Arrhenius equation.

Regarding the biodegradation, the test item was not considered readily biodegradable under the conditions of the modified strum test performed.

With regard to the read across, neither the p- or m- isomer are considered readily biodegradable in OECD 301F or OECD 301B, p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline was only degraded up to 4% within 28 days and the m-isomer substance up to 11%. The m-isomer, in an OECD 302 B study, was not considered to be inherently biodegradable.

An OECD 309 Aerobic Mineralisation study was conducted to simulate potential for ultimate degradation in surface water. Total recoveries of radioactivity (mass balances) for samples treated at 10 μg/L and 100 μg/L were between 97.3 and 110.0% applied radioactivity. Carbon dioxide accounted for a maximum of 15.0% applied radioactivity. After 59 days p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl) aniline accounted for 1.0 to 3.8% applied radioactivity. DT50 values of 10.2 days and 11.4 days were recorded for concentrations of 10ug/L and 100 ug/L respectively.

Analysis of the surface water samples showed that p-(2,3-epoxypropoxy)-N,N-bis(2,3-

epoxypropyl) aniline degraded to 8 major unidentified degradates; polar material and

unknowns 1, 3, 7, 10, 13, 14 and 17, accounting for maximums of 16.8, 11.7, 31.4, 10.2, 12.3, 11.9, 9.4 and 13.1% applied radioactivity, respectively.All other (unidentified) degradation products were present at levels of ≤8.6% applied

radioactivity. Tentative identification of four hydrolysis products and their oxidised forms was made.

The biodegradation in soil was waived in accordance with column 2 of REACh (Regulation (EC) No 1907/2006) Annex IX, the soil simulation testing (required in section 9.2.1.3) does not need to be conducted as direct and indirect exposure of soil is unlikely.

In accordance with column 2 of REACh (Regulation (EC) No 1907/2006) Annex IX, the sediment simulation testing (required in section 9.2.1.2, and 9.2.1.4) do not need to be conducted based on the findings of the Chemical Safety Assessment; the substance does not fulfil classification criteria according to the applicable regulations and does not fulfil the criteria for vPvB or PBT.

The adsorption coefficient was found to be, Log Koc = 1.93 at 20oC. The substance is slightly moblie (according to Guth mobility classification, 1985) and the substance is expected to have a low potential for bioaccumulation as it has a low octanol-water partition coefficient (Log Pow = 0.87)