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Diss Factsheets
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EC number: 225-716-2 | CAS number: 5026-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 21 - June 10, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well-documented pre-guideline study without GLP, testing protocol similar to OECD 402
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- pre-guideline and pre-GLP study
- Principles of method if other than guideline:
- According to: Noakes, D.N. and Sanderson, D.M. (1969). A method for determining the dermal toxicity of pesticides. Brit. J. Indust. Med. 26, pp 59-64.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline
- EC Number:
- 225-716-2
- EC Name:
- p-(2,3-epoxypropoxy)-N,N-bis(2,3-epoxypropyl)aniline
- Cas Number:
- 5026-74-4
- Molecular formula:
- C15H19NO4
- IUPAC Name:
- 4-[(oxiran-2-yl)methoxy]-N,N-bis[(oxiran-2-yl)methyl]aniline
- Test material form:
- liquid: viscous
- Details on test material:
- - Substance type: organic
- Physical state: liquid
- Storage condition of test material: In refrigerator (2-8°C) in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Healthy random bred Rats of 8-9 weeks age were raised on the premises and kept at room temperature of 22 + 2 deg. C, at relatie humidity of 55 +/- 10% and on a 10 hour light cylce day. They received ad libitum rat food (supplier: NAFAG, Gossau, Switzerland) and water. They were adapted to the laboratory for a minimum of 4 days before treatment. During treatment and observation period the animals were housed individually in Macrolon cages type 2.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Approximately 24 hours before treatement an area of approximately 60 square centimeters was shaved with an electric clipper. For the treatment the test material was evenly dispersed on the skin with a syringe and was covered with an occlusive dressing which was fastened around the trunk with an adhesive elastic bandage. After 24 hours the dressing was removed, the skin was cleaned with lukewarm water and the reaction of the skin was appraised.
- Duration of exposure:
- 24 hours
- Doses:
- 0 - 3000 - 3500 - 4000 mg/kg bw Treatment with higher doses was not possible
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations: 1 / hour for the first 5 hours, thereafter at least 1 / day. Body weight determination 1 / week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed during the observation period of 14 days following treatment
- Clinical signs:
- other: Animals treated with 4000 mg/kg bw showed a moderate skin erithema (days 2-8) and a slight skin erythema on day 9. Slight effects recorded are sedation (days 1-5), dyspnea (days 1-6), exophthalmos (days 1-7), ruffled fur (days 1-8) and curved body positi
- Gross pathology:
- No substance related gross organ changes were seen.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute toxicity is similar for males and females. The acute dermal toxicity is >4000 mg/kg bw.
- Executive summary:
The acute dermal toxicity has been investigated in a pre-guideline and pre-GLP study performed and recorded similarly to the later standards. The doses selected were 4000, 3500 and 3000 mg/kg bw. Each 5 male and 5 female animals were treated on the shaved skin (60 cm2) and received an occlusive patch . There was no mortality in all dose groups. At all doses there were the usual clinical symptoms in animals of both sexes. The LD50 derived is >4000 mg/kg.
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