Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-161-1 | CAS number: 78-95-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Hazard evaluation of monochloroacetone
- Author:
- E.V. Sargent
- Year:
- 1 986
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J 47(7); 375
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Chloroacetone
- EC Number:
- 201-161-1
- EC Name:
- Chloroacetone
- Cas Number:
- 78-95-5
- Molecular formula:
- C3H5ClO
- IUPAC Name:
- 1-chloropropan-2-one
- Details on test material:
- purtiy: approx. 93%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 9 weeks old
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test compound was held in contact with imperivious platic sheeting. Collars, desinged to prevent licking, were placed on the necks of the animals.
- Duration of exposure:
- 24 hours
- Doses:
- 50, 100, 200 and 400 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 141 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The dermal LD 50 was determined by Sargent et al to be 141 mg/kg.
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