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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1986
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: literature

Data source

Reference
Reference Type:
publication
Title:
Hazard evaluation of monochloroacetone
Author:
E.V. Sargent
Year:
1986
Bibliographic source:
Am. Ind. Hyg. Assoc. J 47(7); 375

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroacetone
EC Number:
201-161-1
EC Name:
Chloroacetone
Cas Number:
78-95-5
Molecular formula:
C3H5ClO
IUPAC Name:
1-chloropropan-2-one
Details on test material:
purtiy: approx. 93%

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified
Details on test animals or test system and environmental conditions:
9 weeks old

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The test compound was held in contact with imperivious platic sheeting. Collars, desinged to prevent licking, were placed on the necks of the animals.
Duration of exposure:
24 hours
Doses:
50, 100, 200 and 400 mg/kg
No. of animals per sex per dose:
4
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
141 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Remarks:
Migrated information
Conclusions:
The dermal LD 50 was determined by Sargent et al to be 141 mg/kg.