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of the category

Short Chain Fatty Acid Ethyl-, Isopropyl-, Butyl- and 2-Ethylhexyl-Esters

(SCAE C2-C8)


The category includes the following members:


Ethyl linoleate: CAS No: 544-35-4 (MW 308.50).

Ethyl oleate: CAS No: 111-62-6 (MW 310.51).

Fatty acids, essential, ethyl esters: CAS No: 91051-05-7 (MW 256.43-368.64).


Isopropyl laurate: CAS No: 10233-13-3 (MW – 242.40).

Isopropyl myristate: CAS No: 110-27-0 (MW – 270.46).

Isopropyl palmitate: CAS No: 142-91-6 (MW – 298.51).

Isopropyl oleate: CAS No: 112-11-8 (MW – 324.55).


Fatty acids, tall-oil, butyl esters: CAS No: 67762-63-4 (MW 336.56-338.57).

Butyl stearate: CAS No: 123-95-5 (MW 340.59).

Fatty acids, C16-18 and C18-unsatd., branched and linear, Butyl esters: CAS No: 163961-32-8 (MW 312.54-340.60)


2-ethylhexyl oleate: CAS No: 26399-02-0 (MW 394.68).

Fatty acids, C8-16, 2-ethylhexyl esters: CAS No: 135800-37-2 (MW 256.43-312.54).

Fatty acids, C16-18, 2-ethylhexyl esters: CAS No: 91031-48-0 (MW 368.64-396.70).

Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl esters: CAS No: 85049-37-2 (MW – 368.64-396.70).

2-ethylhexyl palmitate: CAS No: 29806-73-3 (MW 368.64)


The category comprises of ethyl, iso-propyl, butyl and 2-ethylhexyl esters, hence the alcohol moiety contains 2-8 carbon atoms. Altogether, the total number of carbon atoms varies between 15 (isopropyl dodecanoate, CAS RN. 10233-13-3) and 26 (ethylhexyl octadecenoate, CAS RN 26399-02-0; this substance or its hydrogenated analogue ethylhexyl octadecanoate are also present in three UVCB chemicals: CAS RNs 135800-37-2, 91031-48-0 and 85049-37-2).


Grouping of these short chain alkyl esters are justified as they are all are characterised by low water solubility on one hand and high Koc/Kow values on the other hand. Furthermore, members of the category are known to be metabolised in fatty acids and their respective alcohol component.


For all members of the SCAE C2-8 category (short chain alcohol ester) no intrinsic effects at the range of water solubility were observed (water solubility < 1 mg/L). No toxicity to fish or microorganisms, E(L)C50 values, were reported at nominal concentrations >100 mg/L. In some daphnia and algae studies physical effects, well above the limit of water solubility, were observed, when unfiltered test substance was present.

In general, three kinds of tests were performed. Effect concentrations as determined in these tests, will be referred as follows within this technical dossier:

a)     direct addition of test material: effect values referred as “test material”

b)     direct addition of test material and extraction by filtration: effect values referred as “filtered test solution”

c)     water accommodated fraction (siphoning of test solution from undissolved test substance): effect values referred as “WAF”