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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Applying a weight-of-evidence approach 1,6-Hexanediol Diglycidylether (HDDGE) is not genotoxic. HDDGE was mutagenic only in the in vitro Ames/Salmonella gene mutation assay. When treatment was in vivo in rats and mice HDDGE induced no evidence of chromosome damage or repairable DNA damage.

Short description of key information:
1,6-Hexanediol Diglycidylether (HDDGE) was evaluated for genotoxic potential in the standard Ames/Salmonella gene-mutation assay and two in vivo tests. HDDGE was positive in the Ames/Salmonella mutation assay. However, HDDGE was negative for induction of chromosome damage in an oral mouse micronucleus test and an in vivo/in vitro rat hepatocyte UDS test.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Data is insufficient for the Classification and Labeling of 1,6-Hexanediol Diglycidylether (HDDGE) as a Mutagen based on negative findings in two in vivo test for genotoxicity.