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EC number: 295-518-9 | CAS number: 92062-05-0 A complex combination of hydrocarbons obtained from the vacuum distillation of the products from a thermal cracking process. It consists predominantly of hydrocarbons having carbon numbers predominantly greater than C34 and boiling above approximately 495°C (923°F).
In an in-vitro dermal absorption study, 200 ul aliquots of neat bituen fume condensate, containing low concentrations of PACs, was applied to the surface of human skin samples fixed in a Franz Diffusion cell. Samples of the receptor fluid were analysed at time intervals ovr a 48hr period following application.
Results show that PACs present in bitumen fume condensate can penetrate the skin.
The rate of dermal flux (ng/cm²/hr±SD) for selected PACs was:
anthracene 6.5 ± 0.9; fluoranthene-pyrene 1.8 ± 0.3; whilst the rate for total 3-6 ring PAC was 120 ± 30.
The amount absorbed over a 48hr period was relatively low; measured values compared to aapplied dose were
anthracene 5.3%, fluoranthene-pyrene 3.3% and 3-6 ring PAC 1.8%.
The permeability coefficient Kp (Kp = flux rate/applied concentration) for anthracene was calculated to be 2 x 10-4 cm/hr.
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