Registration Dossier
Registration Dossier
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EC number: 482-100-8 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The No Observed Effect Concentration (NOEC) and 96 hour LC50 were both greater than 1,000 mg/L loading rate WAF.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
A key study to assess the acute toxicity study of the test substance to zebra fish (Brachydanio rerio) was conducted in accordance with OECD Guideline 203 and SEPA Guideline 203. Based on the results of the preliminary test, a definitive study was conducted using a limit test concentration of 1,000 mg/L (nominal concentration). A concurrent water control group was performed in parallel. The study was performed with a semi-static water renewal system and the water used was reconstituted water. Dissolved oxygen and pH value were determined at the beginning of the test and at 24 hour intervals during the 96 hour exposure period.The measured concentrations of total organic carbon (TOC) were determined in the samples of test media. Samples were taken from each test vessel and analyzed at the beginning and the end of the first and the third 24 hours of the test.
During the 96 hour exposure period, no toxic signs and deaths were observed in either the control or exposure fish. TOC measurements show that there was no significant difference comparing fresh solution with the expired. Because of adding test substance at 1,000 mg/L to the test water the measured concentration of TOC was 0.993 mg/L (i.e. mean of TOC TS-Control).
The No Observed Effect Concentration (NOEC) and 96 hour LC50 were both greater than 1,000 mg/L loading rate WAF.
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