Registration Dossier
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EC number: 202-936-7 | CAS number: 101-37-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to reproduction
Administrative data
- Endpoint:
- extended one-generation reproductive toxicity - with developmental neurotoxicity (Cohorts 1A, 1B without extension, 2A and 2B)
- Type of information:
- experimental study planned
- Study period:
- To be determined.
- Justification for type of information:
- TESTING PROPOSAL ON VERTEBRATE ANIMALS
An Extended One-Generation Reproductive Toxicity Study including assessment for developmental neurotoxicity in the rat is proposed as a standard information requirement as laid down in Annex X, Section 8.7.3. of the REACH Regulation.
NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Triallyl cyanurate
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies: A 28-day and a 90-day oral Repeated Dose Toxicity Study are available, which were conducted in compliance with GLP according to OECD TG 407 or 408, respectively. Furthermore, a Prenatal Developmental Toxicity according to OECD TG 414 was conducted in the rat.
- Available non-GLP studies: none available for toxicity to reproduction endpoint
- Historical human data: no data available
- (Q)SAR: No data available. There are a large number of potential targets/mechanisms associated with reproductive toxicity which, on the basis of current knowledge, cannot normally be adequately covered by a battery of QSAR models. QSAR approaches are currently not well fitted-for-purpose for reproductive toxicity (according to Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7a, Version 5.0, Dez 2016).
- In vitro methods: No accepted alternative in vitro methods to predict developmental toxicity for regulatory use are available (according to Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7a, Version 5.0, Dez 2016).
- Weight of evidence: Insufficient data existing
- Grouping and read-across: No read-across data available.
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- There are no column 2 adaptation posssiblities to address this specific endpoint.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed: an Extended One-Generation Reproductive Toxicity study (OECD 443) with basic test design and developmental neurotoxicity (Cohorts 1A and 1B, without extension, 2A and 2B) will be conducted per oral administration with Triallyl cyanurate.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to
- Guideline:
- OECD Guideline 443 (Extended One-Generation Reproductive Toxicity Study)
- Justification for study design:
- SPECIFICATION OF STUDY DESIGN FOR EXTENDED ONE-GENERATION REPRODUCTION TOXICITY STUDY WITH JUSTIFICATIONS:
- Premating exposure duration for parental (P0) animals: 10 weeks
- Basis for dose level selection: 90-day study (OECD408), developmental toxicity study in rats (OECD414), DRF to be conducted
- Inclusion/exclusion of extension of Cohort 1B: No trigger for the inclusion of cohort 1B were derived from previous studies.
- Termination time for F2: not applicable
- Inclusion/exclusion of developmental neurotoxicity Cohorts 2A and 2B: Obvious functional effects (slight waddling gait, a lack of normal response to toe or tail pinch, an impaired ability for wire maneuver, increased positional passivity, and a lowered resistance on limb rotation) were observed in the 90-day study in absence of histopathological effects in brain, sciatic nerve and spinal cord. Therefore, cohorts 2A and 2B are proposed in order to assess developmental neurotoxicity.
- Inclusion/exclusion of developmental immunotoxicity Cohort 3: No trigger for the inclusion of cohort 3 were derived from previous studies.
- Route of administration: oral (tbd if administration will be via gavage, diet or drinking water)
- Other considerations, e.g. on choice of species, strain, vehicle and number of animals: no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: crystalline
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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