Registration Dossier
Registration Dossier
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EC number: 289-339-5 | CAS number: 87741-01-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Referenceopen allclose all
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- The physiological action of butadiene, butene-2 and isoprene
- Author:
- Larionov, L.F. et al.
- Year:
- 1 934
- Bibliographic source:
- Kazanskii Meditsinkii Zhurnal. 30; 440-445 (HSE translation no. 10855)
- Reference Type:
- publication
- Title:
- Studies on the inhalation of 1,3-butadiene
- Author:
- Carpenter, C.P. et al.
- Year:
- 1 944
- Bibliographic source:
- J Ind Hyg Toxicol 26; 69-78
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
- GLP compliance:
- no
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
Constituent 1
Test animals / tissue source
- Details on test animals or tissues and environmental conditions:
- - Name of test material (as cited in study report): 1,3-butadiene
- CAS number: 106-99-0
- EINECS number: 203-450-8
Results and discussion
Any other information on results incl. tables
Only limited information is available on eye irritation.
Acute exposure to 90,000 - 140,000 ppm butadiene was reported to cause conjunctivitis in mice, and conjunctivitis and lacrimation were observed in rabbits exposed to 150,000-250,000 ppm (Larionov et al., 1934). In another study with rabbits, ophthalmoscopy revealed no signs of eye injury following exposure up to 6,700 ppm butadiene 7.5 hours/day, 6 days/week for 8 months; the same result was recorded for dogs, for which only one animal per exposure level was used (Carpenter et al., 1944).
Eye irritation has been reported in humans at very high exposure concentrations.
The gaseous nature of butadiene precludes the conduct of conventional skin and eye irritation tests in animals.
Applicant's summary and conclusion
- Executive summary:
Mice: Eye irritation at 90,000 - 140,000 ppm.
Rabbits: Eye irritation at 150,000-250,000 ppm, no eye irritation at up to 6,700 ppm daily exposure for 8 months.
Eye irritation has been reported in humans at very high exposure concentrations.
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