Registration Dossier
Registration Dossier
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EC number: 265-196-4 | CAS number: 64742-93-4 A complex black solid obtained by blowing air through a heated residuum, or raffinate from a deasphalting process with or without a catalyst. The process is principally one of oxidative condensation which increases the molecular weight.
Endpoint summary
Administrative data
Description of key information
Several studies in populations of exposed roofing workers are available. These include epidemiological studies, biomarker exposure studies and genotoxicity assays in exposed workers.
Additional information
Exposure related observations in humans
Oxidized Asphalt - DNA Damage
The potential for exposure to oxidized asphalt and it’s emissions to cause DNA damage has been investigated in a small number of occupational studies in asphalt roofing workers (Fuchs et al., 1996, Toraason et al., 2001). These studies monitored workers for the incidence of DNA strand breaks and/or non-specific oxidative damage (8-oxo-dG), primarily in peripheral lymphocytes, following exposure to oxidized asphalt emissions evolved at high temperatures (> 350ºC).
Both studies suffered from investigating effects in only very small sample sizes (seven workers). In addition the Fuchs study had poorly matched controls, incomplete and inconsistent reporting of data and did not control for the effects of smoking.
The Fuchs study showed an increased incidence of DNA strand breaks in the small group of asphalt roofing workers. The conclusions that can be reached from this work are limited however due to the methodological problems. In the study by Toraason and co-workers a small increase in the incidence of DNA strand breaks was reported but there was no effect on non-specific oxidative damage. Methodological problems also limit the conclusions that can be drawn from this study.
In conclusion, the results of two limited occupational studies in asphalt roofing workers show no clear evidence that exposure to oxidized asphalt or it’s emissions causes DNA damage.
Exposure Studies in Roofing Workers
Three studies were identified which used biomarkers ( adduct formation and urinary PAH metabolites) to investigate exposure and uptake in roofing workers. Although results confirmed exposure, the applicability of these studies is limited due to methodological deficiencies and possible confounding exposure to coal-tar.
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