Registration Dossier
Registration Dossier
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EC number: 200-662-2 | CAS number: 67-64-1
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Acceptable, well-documented publication/study report which meets basic scientific principles. Analytical monitoring of test substance concentration was not performed. The test solutions were renewed daily and therefore it can be assumed that the moderate volatility of acetone is of little importance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Malathion on survival, growth, development, and equilibrium posture of bullfrog tadpoles (Rana catesbeliana)
- Author:
- Fordham CL, Tessari JD, Ramsdell HS, Keefe TJ
- Year:
- 2 001
- Bibliographic source:
- Environmental Toxicology and Chemistry 20: 179–184
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 28 d bioassay with bullfrog tadpoles
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetone
- EC Number:
- 200-662-2
- EC Name:
- Acetone
- Cas Number:
- 67-64-1
- Molecular formula:
- C3H6O
- IUPAC Name:
- propan-2-one
Constituent 1
Results and discussion
Any other information on results incl. tables
There was no statistically significant effect of acetone at a concentration of 1 mL/L on mortality, body weight, body length, developmental stage, or equilibrium posture.
Applicant's summary and conclusion
- Conclusions:
- In an 28d bioassay with bullfrog tadpoles (Rana catesbeiana) under semi-static conditions no statistically significant effect of acetone at a concentration of 1 mL/L (790 mg/L nominal) on mortality, body weight, body length, developmental stage, or equilibrium posture was recorded.
- Executive summary:
In an 28d bioassay with bullfrog tadpoles (Rana catesbeiana) under semi-static (renewal: daily) conditions no statistically significant effect of acetone at a concentration of 1 mL/L (790 mg/L nominal) on mortality, body weight, body length, developmental stage, or equilibrium posture was recorded. Based on the test design (renewal of test solution daily) it can be assumed that the moderate volatility of the test substance acetone was of little importance.
Thus the study is regarded as reliable with restrictions.
Results Synopsis
Test organism/age: Rana catesbeiana tadpoles
Test Type: semi-static
28 -d NOEC: 790 mg/L nominal
Endpoint(s) Effected: mortality, body weight, body length, developmental stage, or equilibrium posture
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