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EC number: 204-677-5 | CAS number: 124-07-2
Table 1: Cumulative numbers of juveniles produced per adult alive for 21-days
Mean Cumulative Numbers of juveniles after 21 Days (Mean ± SD)
Inhibition rate (%)
63.0 ± 23.8
67.6 ± 25.0
58.6 ± 21.4
4.6 ± 6.6
0.4 ± 1.1
0.2 ± 0.4
0.2 ± 0.4
*: Indicates a significant difference (α=0.05) from the control.
**: Indicates a significant difference (α=0.01) from the control.
68.1 – 98.9% of the nominal loading of the test substance was determined in the freshly prepared test solutions. The test substance in the aged test solutions decreased during the first 8 days to concentrations below the limit of quantification (10 µg/L).
NOEC (21 d) = 0.2 mg/L, based on reproduction rate of Daphnia magna (OECD 211); RA CAS 334-48-5
Two studies, investigating the long-term toxicity of decanoic acid to aquatic invertebrates, were used as read across to octanoic acid, since the two substances are structurally very similar. Due to an increasing toxicity with increasing chain length from octanoic acid (C8) to lauric acid (C12) towards aquatic invertebrates, the used studies conducted with decanoic acid (C10) are considered as a worst case scenario for the toxicity assessment of octanoic acid.
The first study (Ministry of the Environment of Japan, 1999) with the read across substance decanoic acid was conducted according to OECD 211. Daphnia magna was exposed for 21 d to 5 nominal concentrations of 0.20, 0.64, 2.0, 6.4 and 20 mg/L. The test substance was dissolved in dimethylformamid. The media was prepared and replaced daily. The study resulted in a NOEC (21 d) of 0.2 mg/L (nominal) based on the reproduction rate of the test organism.
A further study (2013) was conducted according to OECD 211 and GLP. Daphnia magna as the test organism was exposed for 21 d to a single concentration of 5 mg/L (nominal). The test item was initially dissolved in acetone. The solvent was left to evaporate before setting up the medium. The eluate was prepared under sterile conditions and replaced daily. The test concentrations were monitored throughout the test duration at three representative 24 h exposure periods per week by GC-MS. 68.1 – 98.9% of the nominal loading of the test substance was determined in the freshly prepared test solutions. The test substance in the aged test solutions decreased during the first 8 days to concentrations below the limit of quantification (10 µg/L). Therefore, the time weighted average (TWA) of the measured concentrations was calculated. The study did not show any biological effects on the mobility, reproduction or growth of Daphnia magna resulting in an NOELR (21 d) of 1.294 mg/L (meas., TWA).
In conclusion, based on the current available information, the most sensitive effect value determined was the NOEC (21 d) of 0.2 mg/L (nominal) which was used for further assessment. A test scheduled in cooperation with Fraunhofer Institute IME (FhG) in Schmallenberg/Germany is still ongoing to overcome methodological deficiencies due to rapid decay of the test substance and to verify the hazard assessment.
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