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EC number: 231-195-2 | CAS number: 7446-09-5
LOAEL (LOEL): maternal toxicity based on reduced body weight gain and food intake PARENTAL TOXIC EFFECTS BY DOSE LEVEL: - Body weight: no effect until mating, from exposure day 13 (ca. GD 4) significant decrease in females of 30 ppm group, p<0.05 - Food consumption: no effect until mating, from exposure day 13 (ca. GD 4) significant concentration-dependent depression for 12-ppm and 30-ppm groups, p<0.05, less marked effect on exposure days 13-17 - Water consumption: significantly depressed on exposure days 9-13 for 12-ppm and 30-ppm groups, p<0.05 - Fertility index: 100 % mated in all groups - Gestational index: 100 % successful pregnancies in all groups
- Behavioral observations - Activity tests inside the exposure chambers (only 12 and 30 ppm groups, single testing due to continuous exposure): significant concentration-dependent increase in the frequency of rearing, sniffing and social interactions shortly after the start of sulfur dioxde exposure, followed by a return to pre-exposure baseline values within 30-60 min; significantly higher effects in males than in females - Behavioral observations - Activity test outside the exposure chambers (all animals, on exposure days 3, 6 and 9): more marked effects in females than in males; dose-dependent decrease of grooming and increase of digging, changes significant on exposure day 9 at 30 ppm in comparison to control, p<0.05; changes in chamber crossing and wall-rearing in females at 30 ppm without dose-dependency as there was a decreasing tendency for the lower test concentrations in comparison to the control EXAMINATION OF FETUSES AND POSTNATAL DEVELOPMENT: No changes of fetotoxicity endpoints, of postnatal somatic and neurobehavioral development as well as of passive avoidance learning and retention
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