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EC number: 273-086-2 | CAS number: 68937-75-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 May - 20 May 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- hardness of test water was lower than that recommended by the Guideline
- GLP compliance:
- yes
- Remarks:
- according to the Japanese GLP Standard
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 and 20 mg/L
- Sampling method: 10 mL test solution was sampled directly from each test vessel at test initiation and after 48 hours.
- Sample storage conditions before analysis: Analysis was conducted immediately after sampling, no storage. - Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test substance was dissolved in vehicle, and this stock solution was diluted in dilution water and stirred for 1 hour.
- Controls: dilution water with/without vehicle
- Chemical name of vehicle: dimethylformamide
- Concentration of vehicle in test medium: 0.1 mL/LGC
- Evidence of undissolved material: not observed - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: Bred in-house (origin: Incorporated Administrative Agency, National Institute for Environmental Studies, Tsukuba, Japan)
- Age at study initiation: max 24 hours
- Feeding during test: no
ACCLIMATION
- Acclimation period: 2 - 4 weeks
- Acclimation conditions: same as test
- Type and amount of food: Chlorella vulgaris, 0.1 - 0.2 mg C/day
- Health during acclimation: 1% mortality was observed - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 55.2 mg/L (as CaCO3)
- Test temperature:
- 19.8 °C (20 ± 1 °C )
- pH:
- 7.7 - 8.1
- Dissolved oxygen:
- 7.5 - 8.5 mg/L (> 60% of saturated oxygen)
- Nominal and measured concentrations:
- nominal concentration: 20 mg/L
measured concentration: 21 mg/L (geometric mean) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL beaker
- Material, fill volume: glass, 100 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration: 4
- No. of vessels per control: 4
- No. of vessels per vehicle control: 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: charcoal-treated, dechlorinated and aerated tap water in Takarazuka, Japan
- Alkalinity: 55 mg/L
- Ca/Mg ratio: 16/3.3
- Culture medium different from test medium: same as test medium
- Intervals of water quality measurement: pH, oxygen content and temperature of test solutions were determined at test initiation and at the end of the study.
OTHER TEST CONDITIONS
- Photoperiod: 16 : 8 hours day-night regime
EFFECT PARAMETERS MEASURED: Mobility observed daily
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: 20 mg/L was the maximum concentration to be dissolved uniformly in dilution water with vehicle (0.1 mL/L)
- Range finding study: performed
- Test concentrations: 20 mg/L
- Results used to determine the conditions for the definitive study: mobility inhibition was not observed - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (reagent grade)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 21 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no abnormality was observed
- Mortality of control: 0%
- Other adverse effects control: not observed - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50: 0.54 mg/L for 48 hours - Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the category justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Source: CAS 334-48-5
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 21 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Source: CAS 334-48-5
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 550 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Source: CAS 124-07-2
Referenceopen allclose all
Table 1: Measured concentration of Decanoic acid during 48 hour exposure
Nominal Concentration (mg/L) |
Measured Concentrations (mg/L) |
Percent of nominal |
||
0 Hours (new)
|
48 Hours (old) |
Mean |
||
Control |
<0.2 |
<0.2 |
- |
- |
Solvent Control |
<0.2 |
<0.2 |
- |
- |
20 |
21 |
22 |
21 |
110 |
Table 2: Immobility of Daphnia magna
Nominal Concentration (mg/L) |
Cumulative Number of Immobilised Daphnia (Percent Immobility) |
|
|
24 Hours |
48 Hours |
Control |
0 (0) |
0 (0) |
Solvent Control |
0 (0) |
0 (0) |
20 |
0 (0) |
0 (0) |
Description of key information
EC50 (48 h) > 21 mg/L (meas. geom. mean) based on mobility of Daphnia magna (OECD 202); RA CAS 334-48-5
Key value for chemical safety assessment
Additional information
Good quality read across data from the two main constituents (decanoic and octanoic acid) of the substance fatty acids, C8 -10 are used to assess the short-term toxicity to aquatic invertebrates.
The read-across study (Ministry of the Environment of Japan, 1999), with Daphnia magna, was conducted according to OECD 202. The test organism was exposed in a static system to a single test item concentration of 20 mg/L (nominal). The test substance was dissolved in 0.1 mL/L dimethylformamide. An analytical monitoring was performed via GC-MS. The study did not show any toxicity effects on the test organism and resulted in an EC50 (48 h) of > 21 mg/L (meas. geom. mean).
Supporting information are available from a study with the read across substance octanoic acid (2001). The test was conducted with the freshwater organism Daphnia magna and nominal test item concentrations of up to 10000 mg/L were tested. The EC50 was found to be 550 mg/L.
In conclusion, no short term toxic effects to aquatic invertebrates up to a concentration of 21 mg/L as worst case is expected from fatty acids, C8 -10, based on read-across data.
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