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EC number: 272-817-2
CAS number: 68915-96-8
A complex combination of hydrocarbons produced by the atmospheric distillation of crude oil. It boils in the range of approximately 288°C to 471°C (550°F to 880°F).
experimental data were located on the toxicokinetics of gas oils in
vivo, hence other information sources must be used to assess the
toxicokinetics of these substances in
vivo, for example data on dermal penetration of jet fuel constituents.
of experimental studies in animals with gas oils provide qualitative
evidence of absorption by the lung, as indicated by a modest increase in
startle reflex in rats inhaling respirable aerosols of diesel fuel.
Physico-chemical considerations also suggest that highly respirable
aerosols of poorly water soluble and highly lipid soluble material will
be absorbed to some extent from the respiratory tract. In the absence of
further guidance, it will be assumed that 50% of an inhaled dose of
aerosolised gas oil will be absorbed in animals and humans.
measured data are available on the dermal absorption of gas oils,
however the occurrence of systemic tissue changes in repeated dose
toxicity studies (in the absence of dermal irritation, and after
controlling for incidental ingestion during grooming) indicates that
some absorption across the skin is possible. Results from the SKINPERM
model indicate that uptake of gas oil across the skin is likely to be
low, with an estimated dermal flux of 0.0001058 mg cm-2 hour
for human skin. However the reliability of this value is not known, and
therefore complete absorption of gas oil by human skin has been assumed
(conservative default) as recommended by the TGD (ECB, 2003). This
assumption is probably highly conservative, given that the log Pow of
the majority (>98.5%) of gas oil components falls outside the 1-4 range
that favours dermal uptake (ECB, 2003). Since experimental studies
demonstrate greater absorption of lipophilic substances by animal skin
compared to human skin, it will be therefore be assumed during risk
characterisation that animal skin is 2-fold more permeable to topically
applied gas oils than is human skin.
in the Straight-Run Gas Oil category are UVCBs; hence it is not possible
to apply standard methodology for assessing absorption, distribution,
and metabolism. Relevant
data for use in risk assessment are available for key constituents.
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