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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties for the acute oral toxicity endpoint.
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from published experimental data (non-standard method) on the analogue Potassium Acetate.
GLP compliance:
no
Test type:
other: read-across from a non-standard study with an analogue

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Potassium acetate
- Molecular formula (if other than submission substance): C2H4O2.K
- Molecular weight (if other than submission substance): 98.142
- Smiles notation (if other than submission substance): [K+].[O-]C(C)=O
- InChl (if other than submission substance): 1/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2.72 other: g/kg bw
Based on:
test mat.
95% CL:
2.07 - 3.56
Other findings:
Based on the experimental results obtained with the analogue Potassium Acetate (LD 50 for male rats = 3.25 (2.48-4.26) g/kg) and the molecular weights, the read-across approach is applied and the LD50 for substance Sodium Acetate is calculated to be 2.72 (2.07-3.56) g/kg.

The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -3.72 for Potassium Acetate and for Sodium Acetate,
- a similar water solubility which is 2.5 g/mL at 20 ºC for Potassium Acetate and 1.25 g/mL for Sodium Acetate at 25 ºC, and
- similar molecular weights which are 98.14 for Potassium Acetate and 82.03 for Sodium Acetate.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for substance Sodium Acetate is calculated to be 2.72 (2.07-3.56) g/kg bw.
Executive summary:

Based on the experimental results obtained (reported under the endpoint record 07.02.01_05 KAc) with the analogue Potassium Acetate (LD 50 for male rats = 3.25 (2.48-4.26) g/kg) and the molecular weights, the read-across approach is applied and the LD50 for substance Sodium Acetate is calculated to be 2.72 (2.07-3.56) g/kg bw.