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EC number: 229-722-6 | CAS number: 6683-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- purity not indicated, body weighs not given, no data for individual animals
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no data for single animals, body weight not recorded.
- Principles of method if other than guideline:
- 20 young adult rats were used in this study to determine the range of toxicity. The material was administered to ether-sedated fasted animals as a suspension in DMSO/corn oil (50/50) heated to 50 °C. Controls were given DMSO/corn oil (50/50) only. The dose was given intragastrically with a ball-tipped needle and syringe. After treatment, all animals were observed daily for 30 days for aberrant physiological and behavioral responses
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
- EC Number:
- 229-722-6
- EC Name:
- Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
- Cas Number:
- 6683-19-8
- Molecular formula:
- C73H108O12
- IUPAC Name:
- 3-{[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}-2,2-bis({[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}methyl)propyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Constituent 1
- Specific details on test material used for the study:
- - Storage condition of test material: 25 °C in a glass container sealed inside a polyethylene bag
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 67 days
- Weight at study initiation: 250 - 270 g
- Fasting period before study: Yes
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: DMSO/corn oil (50/50)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 500 mg/mL
- Justification for choice of vehicle: Insoluble in water
DOSAGE PREPARATION (if unusual): 5 g of test material were dissolved in 5 mL of DMS0 at 50 °C. This solution was diluted with 5 mL of corn oil, which formed a suspension of the test substance in the liquid medium. This suspension was kept at 50 °C until administration was completed.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Preliminary study - Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 30 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: aberrant physiological and behavioral responses
Results and discussion
- Preliminary study:
- Because the LD50 was greater than 5 g/kg, the material was considered to be nontoxic.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- >= 5 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: The report gives a general assessment that all behavioural and physiological responses were normal.
- Gross pathology:
- not mentioned
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Because the LD50 was greater than 5 g/kg, the material was considered to be nontoxic.
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