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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to terrestrial plants

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Administrative data

Link to relevant study record(s)

toxicity to terrestrial plants: long-term
Data waiving:
other justification
Justification for data waiving:
according to guideline
OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)

Description of key information

Key value for chemical safety assessment

Additional information

No toxicity to terrestrial plants data are available with the registered substance, octamethylcyclotetrasiloxane (D4, CAS 556-67-2, EC No. 209-136-7).

D4 falls under soil Hazard Category 3 (indication for high adsorption based on log Kow >3, but no indication of aquatic toxicity (no effects in aquatic studies)). For Hazard Category 3 substances, a confirmatory long-term study is required: the above reported OECD TG 222 study was conducted. ECHA guidance Chapter R.7c (ECHA 2017) states the following: “If PEC/PNECscreen >1 or indication of risk from confirmatory long-term soil toxicity test: Conduct long-term toxicity tests according to the standard information requirements Annex X (invertebrates and plants), choose lowest value for derivation of PNECsoil”.

In accordance with the ECHA guidance and with ECHA decision number TPE-D-2114422498-44-01/F, because effects were observed in the OECD TG 222 earthworm study as well as the soil microorganisms study, a long-term toxicity to terrestrial plants study is required. 

A long-term toxicity to terrestrial plants study in accordance with OECD TG 208 has therefore been contracted and is expected to be completed by June 2023. A timeline for completion of the study is included in IUCLID Section 6.3.3 Toxicity to Terrestrial Plants endpoint study record.