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EC number: 229-176-9 | CAS number: 6422-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable shot-term (acute) and long-term (chronic) aquatic toxicity test data are available for this substance for the three principle trophic levels: primary producers, represented by algae; plant eating animals, represented by daphnids; and predators, represented by fish. In addition, results from an activated sludge respiration inhibition study are also available. These studies were conducted at concentrations near or above the water solubility limit for this substance which is very low (0.4 µg/L). None of the short-term or long-term aquatic toxicity studies exhibited toxic effects at the limit of water solubility (i.e., NOEC > water solubility). For the primary producer trophic level an OECD Guideline 201 algal growth inhibition study was conducted under GLP. In this study no inhibition of growth or biomass was observed at the highest measured test concentration of 0.86 mg/L (NOEC ≥0.86 mg/L), which is several orders of magnitude above the water solubility limit. Short-term acute toxicity studies with three different species of invertebrates have been conducted. A pre-GLP 96-hour acute toxicity test was conducted with planorbid snails (H. trivolvis) at nominal concentrations up to 984 mg/L under static conditions. There was no mortality or abnormal effects observed at 984 mg/L (NOEC ≥984 mg/L). A 48-h static acute OECD 202 toxicity limit test conducted withDaphnia magna under GLP resulted in a NOEC of ≥ 1.4ug/L. Eastern oysters (C. virginica) in a 96-h acute toxicity study, were exposed at measured concentrations of 0, 30.3, 168, and 624 µg/L under flow-through conditions. There was no mortality or inhibition in shell deposition observed at any of the exposure concentrations during this study. The 96-h NOEC value was ≥ 624 µg/L, the highest concentration tested.
Long-term (chronic) toxicity to invertebrates was evaluated in a 21-d study utilizing Daphnia magna. The organisms were exposed at measured concentrations up to 0.76 µg a.i./L under flow-through conditions. No differences in survival, growth (length and/or dry weight), or reproduction (cumulative young produced) was observed among organisms in this study. The 21-d NOEC value was ≥0.76 µg a.i./L for this study.
Short-term (acute) toxicity to fish was evaluated using two different species. A pre- GLP 96-h acute toxicity was conducted utilizing fathead minnows (P. promelas). The organisms were exposed at nominal concentrations of 0, 98.4, and 984 mg/L under static conditions. There was no mortality or abnormal effects observed at 984 mg/L (1000 uL/L), the highest exposure concentration during this study. The 96 -h NOEC value was ≥ 984 mg/L. A second study under GLP was conducted with Rainbow trout (O. mykiss). In that 7-day acute toxicity study, the organisms were exposed at measured concentrations of 0, 0.013, 0.021, 0.038, 0.080, and 0.25 mg/L under flow-through conditions. There was no mortality or abnormal effects observed at any of the exposure concentrations during this study. The 7-day NOEC value was 0.25 mg/L, the highest concentration tested.
Long-term (chronic) toxicity to fish was evaluated in a 71-d toxicity study with rainbow trout. Eggs and fry were exposed at measured concentrations up to 0.28 mg/L under flow-through conditions. No differences in hatchability, survival, or growth (standard length and/or wet weight) were observed among organisms in this study. The 60-day post-hatch NOEC value was >= 0.28 mg/L.
Sewage sludge microorganisms were exposed in a 3-hour toxicity study at nominal concentrations of 0, 0.1, 0.3, 1.0, 3.2, and 10 mg/L under static conditions. There was no inhibition of respiration rate observed at any of the exposure concentrations during this study. The 3-hour NOEC value was ≥ 10 mg/L, the highest concentration tested. The substance is not expected to inhibit respiration of secondary waste treatment microorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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