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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-974-4 | CAS number: 101-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in air
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in air
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Method: other (measured)
- GLP compliance:
- no
- Details on test conditions:
- Sensitiser (for indirect photolysis): OH
Sensitiser concentration: up to 100000000 molecule/cm³
Test condition: Reaction chamber 420 l, at atmospheric pressure and 298 +/-2 degree K. Irradiation by 24 Philips TL/05 40W lamps (k photolysis = 0.0062/sec, similar to natural sunlight) and OH radicals generated by photolysis of methyl nitrite in air at wavelengths >300 nm, in presence of nitric oxide to prevent formation of ozone and nitrate radicals. Concentration-time profiles of test substance were determined using in-situ long-path FT-IR absorption spectroscopy. A competitive rate technique, using toluene as reference substrate, obviated the need for precise knowledge of substrate concentrations.
Test medium: Air containing <40ppm of water
Positive Controls: Toluene
Concentrations of test substances were 1-5 ppm (0.005-0.040 mg/l) for TDA and MDA. - Temp.:
- 25 °C
- DT50:
- 6.4 h
- Transformation products:
- yes
- Conclusions:
- It was concluded that no accumulation of atmospheric MDA would be predicted from an emission of MDA.
Reference
Rate constant (for indirect photolysis): = 0.00000000003 cm³/(molecule*sec)
Description of key information
A tropospheric half-life time of 6.4 hours has been determined based on a tropospheric hydroxyl radical concentration of 1 x 10(6)/ml. A rapid photodegradation is expected when exposed to air.
Key value for chemical safety assessment
- Half-life in air:
- 6.4 h
- Degradation rate constant with OH radicals:
- 0 cm³ molecule-1 s-1
Additional information
The study provides a rate constant of 3 x 10-11cm3/mole*sec for the indirect photolysis of MDA. A tropospheric half-life time of 6 hour was calculated assuming a tropospheric hydroxyl radical concentration of 1 x 106/ml (Becker al, 1988). These results are consistent with those obtained by QSAR (Pemberton et al., 2008) |
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