Registration Dossier
Registration Dossier
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EC number: 241-164-5 | CAS number: 17095-24-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
- Principles of method if other than guideline:
- Expert system (knowledge-based). See further info attached and reference publication:
Gadaleta, D., Manganelli, S., Manganaro, A., Porta, N., & Benfenati, E. (2016). A knowledge-based expert rule system for predicting mutagenicity (Ames test) of aromatic amines and azo compounds. Toxicology, 370, 20-30.
Test material
- Reference substance name:
- Tetrasodium 4-amino-5-hydroxy-3,6-bis[[4-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]azo]naphthalene-2,7-disulphonate
- EC Number:
- 241-164-5
- EC Name:
- Tetrasodium 4-amino-5-hydroxy-3,6-bis[[4-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]azo]naphthalene-2,7-disulphonate
- Cas Number:
- 17095-24-8
- Molecular formula:
- C26H25N5O19S6.4Na
- IUPAC Name:
- tetrasodium 4-amino-5-hydroxy-3,6-bis[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- The analyzed azo dye presents one azo bonds that can have a clevage with consequent generation of amine mutagenic products (Øllgaard et al., 1998; Weber and
Adams,1995).
Results and discussion
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
Any other information on results incl. tables
A compound with high degree of similarity with the target is the Navy MGI 1319, EC number 432-100- 9, that has experimental value non mutagen and is predicted by the model as non-mutagen, similarly to Reactive Black 5.
Applicant's summary and conclusion
- Conclusions:
- non mutagen
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