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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
UGI (Upgraded Ilmenite) shows very low release rates of titanium ions following exposure in different artificial biological media for 2 and 24 hours. The titanium dioxide pigment grade sample, tested for comparative reasons, shows release rates of a similar low quantity.

Key value for chemical safety assessment

Additional information

In all, the released concentrations of titanium ions from all test items (often close to the limit of detection 0.12 g/L) were generally low. The titanium release was influenced by the composition and pH of the test media. The released concentrations increased with solution acidity, i.e. GMB <= PBS < ALF <= GST.

UGI (Upgraded Ilmenite) consists primarily of a titanate phase (solid solution) most of which is Ti in an oxidised form. Any material being released from UGI under physiological conditions will be in the form of ionic titanium, which is similarly the case for titanium dioxide: more specifically, the results from in vitro bioaccessibility testing in such fluids demonstrate a similar dissolution pattern of UGI and titanium dioxide, thus read-across from toxicity data on titanium dioxide is considered feasible without any restrictions. Thus, the point of departure derived from repeated dose toxicity/carcinogenicity studies which were conducted with titanium dioxide will be used for the DNEL derivation of UGI. Please refer to the report on DNEL derivation for further information (attached to the endpoint summary for section 7 of the IUCLID)