Registration Dossier
Registration Dossier
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EC number: 204-589-7 | CAS number: 122-99-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- COMPARISON OF CYTOTOXIC EFFECTS OF CHEMICALS IN FOUR DIFFERENT CELL TYPES
- Author:
- Sasaki, K. et al.
- Year:
- 1 991
- Bibliographic source:
- Toxic. in Vitro 5(5/6): 403-406
Materials and methods
- Type of study / information:
- Cytotoxicity
- Principles of method if other than guideline:
- Cytotoxic effects were compared using a colony-formation assay in three established cell lines (BaIb 3T3, mouse whole embryo, ARLJ301-3, rat liver and FRSK, rat keratinocytes) and one primary cell culture (RC-1, rabbit cornea) with the Draize eye irritancy score in vivo.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-phenoxyethanol
- EC Number:
- 204-589-7
- EC Name:
- 2-phenoxyethanol
- Cas Number:
- 122-99-6
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 2-phenoxyethan-1-ol
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Phenoxyethanol
- Analytical purity: no data
Results and discussion
Any other information on results incl. tables
These results suggest that the colony-formation assay using established cell lines is an attractive method for the screening of chemicals in that large differences among cell types in their response to direct-acting chemicals, were not observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
