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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
other: review article
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature (from review article with incomplete experimental data)

Data source

Reference
Reference Type:
publication
Title:
Final report on the safety assessment of triacetin.
Author:
Fiume, M.Z.
Year:
2003
Bibliographic source:
Int J Toxicol. 2003;22 Suppl 2:1-10.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
review article with incomplete experimental data
Principles of method if other than guideline:
The acute dermal LD50 of Triacetin was determined using groups of five albino rabbits.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): triacetin
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
A dose of 5 g/kg bw was applied to intact and abraded skin.
Duration of exposure:
single application
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
The animals were observed for 7 days after dosing.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Remarks on result:
other: rabbit
Mortality:
None of the animals died.

Any other information on results incl. tables

The dermal LD50 of Triacetin for rabbits was >5 g/kg bw.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU