Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study from reliable laboratory, report available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994
Report Date:
1993

Materials and methods

Principles of method if other than guideline:
hepatocytes from male Sprague Dawley rat liver were isolated and exposed to atmospheres of HFC-143a for 4 days. At the end of the exposure, palmitoyl-CoA-oxidase activity was measured.
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test material identified as Forane 143A in report

Results and discussion

Any other information on results incl. tables

No increase in palmitoyl-CoA-oxidase activity was seen. It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days.

Applicant's summary and conclusion

Conclusions:
No increase in palmitoyl-CoA-oxidase activity was seen. It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days at exposure levels up to 80% in the atmosphere above the cells.
Executive summary:

It was concluded that HFC-143a is not a peroxisome inducer in vitro in rat hepatocytes in primary cultures treated for 4 days at exposure levels up to 80% in the atmosphere above the cells when tested by measuring palmitoyl-CoA-oxidase activity.