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EC number: 247-148-4
CAS number: 25637-99-4
Erythema/Edema scores per animal (intact skin):
Erythema/Edema scores per animal (abraded skin):
male and 3 female New Zealand White rabbits
used for this study.
hair was removed from the back of each rabbit (20-30% of
the body surface) with an electric clipper. The skin of 3 of
the rabbits was abraded by making shallow incisions with a scalpel
blade, not sufficiently deep to cause bleeding.
mg of the test material was applied to the back
of each rabbit using 0.9% Physiological Saline as a wetting agent.
The application sites were then covered with gauze bandaging and
occluded with Saran Wrap. Four hours later the bandages were removed
and the sites were washed with tepid tap water and examined for
skin irritation. These examinations
were repeated at 24, 48 and 72 hours.
Based upon the irritation scores
obtained the registered substance does not meet the criteria for
classification set out in 67/458/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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