Registration Dossier
Registration Dossier
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EC number: 203-431-4 | CAS number: 106-79-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The profil of the substance is assessed using its physical and chemical properties as requested by the R7 c Reach guidance. Indeed, there were no studies available in which the toxikokinetic properties (absorption, distribution, metabolism, elimination) of dimethylsebacate were investigated. Based on the molecular structure, molecular weight, water solubility, and octanol-water partition coefficient oral, dermal and inhalative absorption can not be excluded.
Key value for chemical safety assessment
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
No reliable ADME studies are available for dimethyl sebacate. The absorption rate for oral, dermal and inhalation is therefore considered as 100% by default.
According to the REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolism and excretion should be analysed from the physicochemical properties, including:
-Molecular weight: 230.3 g/mole
-Water solubility: 0.3 g/l (moderately soluble)
-Partition coefficient Log Kow: 3.38
-Vapour pressure: 0.0008 mbar (20°C)
ABSORPTION
Oral :
The value of log Kow (between 1 and 4) and the moderate water solubility (0.3 g/l) are in the range suggestive of favourable absorption from the gastro-intestinal tract subsequent to oral ingestion. Furthermore the molecular weight (< 500 g/mole) is suggestive of absorption.
Dermal:
The molecular weight of 230.3 g/mol associated with a Log P ranged between 1 and 4 is suggestive of a moderate dermal absorption according to guidance criteria.
Inhalation
Based on the very low value of the vapour pressure , Dimethyl sebacate is not considered as a volatile substance. However inhalation exposure may occur during specific tasks and taking into account the low molecur weight, the moderate solubility and the logP (between -1 and 4) favourable absortion is expected.
DISTRIBUTION and METABOLISM
Takin into account the moderate water solubility and the Log P <4 , Dimethyl Sebacate is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues. However, no systemic effects were observed in the oral combined repeated toxicity study in rats.
No specific data is available on the metabolism of Dimethyl Sebacate.
ELIMINATION
Due to the moderate water solubility and a low molecular mass (near to 230.0 g/mol), the excretion of Dimethyl Sebacate in the urines is expected.
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