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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The 21-d NOEC for MTBE in Daphnia magna is 51 mg/l, applying a safety factor of 10 results in an NOEC of 5.1 mg/l for ETBE. For marine invertebrates the 28-d NOEC is 3.39 mg/l in Americamysis bahia.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
5.1 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
3.39 mg/L

Additional information

One chronic test with marine invertebrates is available; the study is conducted according to accepted guidelines. The 28-d NOEC in Americamysis bahia is 3.39 mg/l (T. R. Wilbury Laboratories, Inc., 2004). No chronic studies with freshwater invertebrates are available. A guideline study is available for MTBE with Daphnia magna, the 21-d NOEC is 51 mg/l (Wildlife International Ltd., 1999). A safety factor of 10 is applied to this value, resulting in an effect concentration of 5.1 mg/l for TAME. Such an approach is conservative since a QSAR predicts that the toxicity of TAME is only a factor of 2 more toxic that MTBE. These values are used in the assessment. Such a conservative approach is further supported by the QSAR. This appears to over predict toxicity for these ethers and the QSAR predicted value for TAME chronic toxicity to daphnia magna is 10mg/l, which is greater than the value derived from MTBE using the assessment factor of 10.