Registration Dossier
Registration Dossier
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EC number: 213-611-4 | CAS number: 994-05-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 is 580 mg/l in the freshwater fish Onchorhynchus mykiss. For marine fish the 96-h LC50 is 574 mg/l for MTBE found in Menidia beryllina; a safety factor of 10 will be applied on this value.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 580 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 57.4 mg/L
Additional information
There are three guideline studies available for freshwater fish. The studies are either semi-static or flow-through. The most critical study is therefore chosen as the key study. The lowest observed effect concentration is a 96-h LC50 value of 580 mg/l in Onchorhynchus mykiss (Springborn Laboratories Inc., 1994a). As no data is available for marine fish, the data from MTBE are used for read-across. The lowest effect concentration in marine fish for MTBE is a 96 -h LC50 of 574 mg/l in inland silverside (Menidia beryllina) (BenKinney et al., 1994). Applying a safety factor of 10 to this value results in an effect concentration of 57.4 mg/l for TAME. Both values will be used in the assessment.
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