Registration Dossier
Registration Dossier
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EC number: 249-079-5 | CAS number: 28553-12-0
Endpoint summary
Administrative data
Description of key information
Additional information
DINP has been tested with multiple aquatic organisms in acute and chronic studies. The results demonstrate that DINP does not cause any adverse effects within the limits of water solubility. In addition the test conducted with amphibia (Moor frog) also did demonstrate the absence of adverse effects on the development of the larvae exposed up to 858 mg/kg sediment (d.w.).
DINP does not produce acute or chronic aquatic toxicity in fish, invertebrates, and algae. It has also been shown not to adversely impact the population parameters evaluated in a multi-generation study with a fish species, demonstrating that DINP does not have the potential to cause endocrine disruption in the aquatic environment. The absence of toxicity demonstrated by DINP is, at least in part, due to its low water solubility, resulting in low exposure potential, as well as the ability of organisms to metabolize DINP at a rate that prevents a critical body burden from being reached. The data for DINP show that it is not toxic at its maximally attainable water solubility level, which varies dependent on the conditions of study. Since DINP does not cause acute or chronic aquatic toxic effects at the limits of water solubility, it is not possible to derive NOEC or PNEC values needed for quantitative risk assessment. However, it is possible to qualitatively conclude based on low solubility and the results of acute and chronic aquatic toxicity tests that DINP does not pose an unacceptable risk to the aquatic compartment.
LITERATURE RELATED TO DINP ENDOCRINE DISRUPTION POTENTIAL IN AQUATIC ORGANISMS PUBLISHED BETWEEN 2014 TO 2022:
A literature search allowed identifying a number of papers conducting tests of potential interest regarding the ecotoxicological effects of DINP. However, after assessment it was concluded that all of them present significant reporting omissions or methodological flaws, rendering them not useful for regulatory assessment (Klimisch 3 and 4). For transparency, the RSS for those papers are included in this update.
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