Zirconium sulphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable non-GLP study reporting on the acute oral toxicity of a 25% zirconium sulfate solution. Limited information on test substance and methods employed.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1950

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Zirconium sulphate

EC Number:

238-694-4

EC Name:

Zirconium sulphate

Cas Number:

14644-61-2

Molecular formula:

H2 O4 S . 1/2 Zr

IUPAC Name:

zirconium(4+) disulfate

Details on test material:

- Name of test material (as cited in study report): zirconium sulfate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: adult rats
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: maintained in air-conditioned rooms
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

25% aqueous solutions were used.

Doses:

Single dose, no more data

No. of animals per sex per dose:

22 rats in total

Control animals:

no

Details on study design:

- Duration of observation period following administration: 10 days

Statistics:

The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

3 500 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 253 mg/kg bw

Based on:

element

Remarks:

Zr

Mortality:

The rats showed a progressive depression and decrease in activity until death occurred.
No sex differences were noted, and the LD50 value was therefore derived from the combined data on both sexes.
The time of death varied from a few hours to a few days after administration. Few deaths however occurred later than 5 days after administration.

Clinical signs:

other: No characteristic physiologic changes were observed.

Gross pathology:

No characteristic gross pathologic changes were observed.

Applicant's summary and conclusion

Conclusions:

The acute oral LD50 in rats via gavage is 3500 mg/kg bw for zirconium sulfate.