Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of butyl cellosolve solvent.
- Author:
- Carpenter CP, Pozzani UC, Weil CS, Nair JH, Keck GA, Smyth HF
- Year:
- 1 956
- Bibliographic source:
- AMA Arch. Ind. Health 14, 114-131
Materials and methods
- Principles of method if other than guideline:
- Method: other: 24-hour occlusive dermal application
- GLP compliance:
- not specified
- Test type:
- other: Skin penetration toxicity
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: "Cellosolve"
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- animal age: 3-5 months
animal weights: 2.3-3.3 kg
Administration / exposure
- Type of coverage:
- other: impervious sheeting
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 2.24-5.66 mL/kg as stated in publication; calculated values: 2083-5264 mg/kg
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.56 mL/kg bw
- Remarks on result:
- other: Value corresponds to 3271 mg/kg (with a density of 0.919 at 25 °C)
Any other information on results incl. tables
The administration of the test substance by inunction on the rabbit skin led to a LD50 of 16.3 mL/kg (range 13.2 -20.2 mL/kg)
Applicant's summary and conclusion
- Conclusions:
- The LD50 for rabbits by skin penetration with the test substance 2-ethoxyethanol has been determined to be 3.56 mL/kg. The corresponding value for an uncovered skin treatment (rubbed into skin by gentle massage) was 16.3 mL/kg.
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