Lead dinitrate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No GLP, relatively poor documentation

Data source

Reference

Reference Type:

publication

Title:

Single oral toxicity of various organic compounds

Author:

Kinkead E.D., Wolfe R.E

Year:

1992

Bibliographic source:

Journal of the American College of Toxicology; 1992; 11:713

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lead acetate

EC Number:

239-379-4

EC Name:

Lead acetate

Cas Number:

15347-57-6

IUPAC Name:

lead(4+) tetraacetate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

no details

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

no details

Doses:

2500, 5000, 6300, 7940, 10000

No. of animals per sex per dose:

5 males and 5 females

Control animals:

no

Results and discussion

Any other information on results incl. tables

Five male and five female Sprague-Dawley rats were used per dose level. Water soluble compounds were administered in distilled water. Compounds that would not dissolve in water were administered as suspensions in corn oil. All rats were fasted prior to dosing and the gavage volume was maintained: at 0.01 mL/g body weight. All survivors were maintained for a 14-day observation period.

Geometrically spaced doses were administered to determine the LD₅₀. Calculations were by moving average interpolation method of Weil, Biometrics 1952(8) 249-263.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

For lead acetate LD50 values of 4665 (3153 -6900) and 5610 mg/kg bw have been observed for male and female rats, respectively. It is reasonable to assume that the toxicity of lead salts is triggered by the lead cation and not the corresponding anion. Therefore, it is considered justified to use data from lead acetate also for other soluble lead salts like lead dinitrate. As the molar mass of lead acetate and lead dinitrate is almost identical the LD50 value for lead acetate is also applicable for lead dinitrate.

Executive summary:

Five male and five female Sprague-Dawley rats were used per dose level. Lead acetate was administered in distilled water. All rats were fasted prior to dosing and the gavage volume was maintained: at 0.01 mL/g body weight. All survivors were maintained for a 14 -day observation period.

Geometrically spaced doses were administered to determine the LD₅₀. Calculations were by moving average interpolation method of Weil, Biometrics 1952(8) 249-263.

For lead acetate LD50 values of 4665 (3153 -6900) and 5610 mg/kg bw have been observed for male and female rats, respectively.

It is reasonable to assume that the toxicity of lead salts is triggered by the lead cation and not the corresponding anion. Therefore, it is considered justified to use data from lead acetate also for other soluble lead salts like lead dinitrate. As the molar mass of lead acetate and lead dinitrate is almost identical the LD50 value for lead acetate is also applicable for lead dinitrate.