Registration Dossier
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EC number: 200-291-6 | CAS number: 56-84-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A weight of evidence approach is applied, based on data for L-aspartic acid, a read across to data for the analogous substances succinic acid, a further read across to results of other aquatic toxicity tests with L-aspartic acid and on QSAR estimations. The resulting IC50,72h is higher than 113 mg/L. The NOECalgae (72 h, pH adjustment) = 100 mg/L
A more detailed discussion of the weight of evidence approach is presented in Section 6.1 'Aquatic Toxicity'.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 113 mg/L
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
The IC50,72h determined was >100 mg succinic acid/L. This is transcribed to L-aspartic acid, considering the slightly different molecular weights. The NOECalgae (72 h, pH adjustment) = 100 mg/L
The study with L-aspartic acid is considered to be not adequate for REACH because no adjustment of the pH was applied in the test vessels. The observed inhibition of the algae growth is obviously due to low pHs (down to pH 4.3) at the highest concentrations used. and not on specific target organ toxicity.
A more detailed discussion of the weight of evidence approach is presented in Section 6.1 'Aquatic Toxicity'.
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