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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study not available. (cited in US EPA memorandum dated March 23, 1990).
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Principles of method if other than guideline:
other: 21 days dermal irritation study
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dichlorobenzene
EC Number:
203-400-5
EC Name:
1,4-dichlorobenzene
Cas Number:
106-46-7
Molecular formula:
C6H4Cl2
IUPAC Name:
1,4-dichlorobenzene
Details on test material:
no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
other:
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
21 days
Frequency of treatment:
5 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
300 mg/kg/day
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels

Basis for effect level:
other: see: executive summary
Remarks on result:
not measured/tested
Remarks:
Effect level not specified (migrated information)

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

no significant dermal irritation was observed

Applicant's summary and conclusion

Executive summary:

A 21 -day dermal toxicity study (GLP) in SD rats up to 300 mg/kg/day of 1,4 -dichlorobenzene in mineral oil, failed to elicit any toxic effects or significant dermal irritation but the highest dose tested did nor reflect a limit dose.