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EC number: 246-690-9 | CAS number: 25167-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Flash point
- Auto flammability
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- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
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- Nanomaterial agglomeration / aggregation
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4,4-trimethylpentene
- EC Number:
- 246-690-9
- EC Name:
- 2,4,4-trimethylpentene
- Cas Number:
- 25167-70-8
- Molecular formula:
- C8H16
- IUPAC Name:
- 2,4,4-trimethylpent-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 2,4,4-trimethylpentene (also known as diisobutylene and diisobutene)
- Physical state: clear, colourless liquid
- Analytical purity: 95.19%
- Lot/batch No.: Batch No. 2 (a 50:50 mixture of two original batches of 2,4,4-trimethylpentene - the details of which are as follows: Batch No. R11 supplied by Shell and Batch No. 155833 supplied by Erdolchemie).
- Expiration date of the lot/batch: 29 April 1997
- Storage condition of test material: Under nitrogen, protected from light, in a cool store.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD (remote Sprague-Dawley origin)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited, Margate, Kent, England
- Age at study initiation: Approximately 5 weeks
- Weight at study initiation (day -1): 122-133 g (males); 118-134 g (females)
- Fasting period before study: overnight prior to dosing and 4 hours following dosing
- Housing: Stainless steel grid cages . Five animals of the same sex / cage.
- Diet: Complete pelleted rodent diet (RM1(E) SQC, from Special Diets Services Limited, Witham, Essex, England ad libitum except overnight prior to, and for 4 hours after, dosing.
- Water: Tap water ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 18-28°C
- Humidity: 54-70%
- Air changes: At least 10/hr
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 23 May 1996 To: 6 June 1996
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Prepared at the appropriate concentration in maize oil to permit administration at a constant volume-dosage of 10 mL/kg - Doses:
- 2000 mg/kg bodyweight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were recorded 3 times on day 1 and daily thereafter. Bodyweights were recorded on the day before dosing and on days 1,8 and 15
- Necropsy of survivors performed: yes - Statistics:
- Not applicable (limit test, no mortalities)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities
- Clinical signs:
- other: other: No abnormalities
- Gross pathology:
- There was a single case of hydronephrosis of the kidney
Applicant's summary and conclusion
- Interpretation of results:
- other: low oral toxicity
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dosage (LD50) of 2,4,4-trimethylpentene was greater than 2000 mg/kg. 2,4,4-Trimethyl pentene is considered to be of low oral toxicity.
- Executive summary:
A group of 5 male and 5 female CD rats (fasted overnight) were dosed by gavage at 2000 mg/kg of 2,4,4 -TMP (in maize oil) and were observed daily for 14 days after dosing. Bodyweights were recorded weekly during the observation period. There were no mortalities and no signs of toxicity. All animals gained weight and there were no significant necropsy findings. The acute oral median lethal dosage (LD50) of 2,4,4-trimethylpentene was greater than 2000 mg/kg. 2,4,4-trimethyl pentene is considered to be of low oral toxicity and does not require classification under DSD or CLP.
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