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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; endpoint record transferred from IUCLID 4

Data source

Referenceopen allclose all

Title:
No information
Author:
Kel'man, G.Ya., Gig. Trud. Prof. Zabol. 9(8), 32-36 (1965)
Title:
No information
Author:
Kel'man, G.Ya., Soviet Rubber Technol. 24, 40-41 (1965)

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
EC Number:
500-051-3
EC Name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
Cas Number:
26780-96-1
Molecular formula:
(C12H15N)x
IUPAC Name:
2,2,4-trimethyl-1,2-dihydroquinoline

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
20 w
Frequency of treatment:
4 h/d, daily
Doses / concentrations
Remarks:
Doses / Concentrations:
2.5, 12.5 mg/l
Basis:

Control animals:
other: no data specified
Details on study design:
Post-exposure period: 30 d

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
low dose: slight decrease in body weight gain, diminution of
the antitoxic function of the liver, recovery within 30
days; high dose: decrease in body weight gain, depression of
the antitoxic function of the liver, a lowering of
albumens and an increase of gamma-globulin concentrations,
reduction in the intensity of the gas exchange, recovery
within 30 days

Applicant's summary and conclusion