Registration Dossier
Registration Dossier
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EC number: 213-879-2 | CAS number: 1047-16-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (no information on test item purity and composition, no information on exposure duration, no details on animals and housing conditions), deviating from existing guidelines (only 3 animals/group)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
- Principles of method if other than guideline:
- test for acute dermal toxicity
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- EC Number:
- 213-879-2
- EC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 1047-16-1
- Molecular formula:
- C20H12N2O2
- IUPAC Name:
- 5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 2 mL/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- The test substance was applied onto intact or abraded skin (3 animals for each condition)
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 mL/kg bw
- Remarks on result:
- other: no animals died within the 14 day observation period
Any other information on results incl. tables
- no deaths occurred
- body weight development was not impaired
Applicant's summary and conclusion
- Conclusions:
- Single application of 2 mL of test substance per kg bw onto the intact or abraded skin of rabbits did not cause lethality during the 14 days observation period, thus resulting in a LD50 > 2 mL/kg bw. This study was judged not to be reliable, because relevant information (e.g. test item purity, duration of exposure) are missing. Nevertheless, these data support the results obtained with other members of this category, which did not show acute dermal toxicity, too.
- Executive summary:
6 Rabbits were subjected to test acute dermal toxicity. The test substance was administered on the skin
(3 animals had intact skin, 3 animals had abraded skin) at a dose of 2 mL/kg bw. No animal died within the observation period, resulting in a LD50 > 2 mL/kg bw.
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