Registration Dossier
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EC number: 240-245-2 | CAS number: 16090-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolic behaviour of water-soluble fluorescent whitening agents in the rat and bean plant
- Author:
- Muecke W, Dupuis G, Esser HO
- Year:
- 1 975
- Bibliographic source:
- Environmental Quality and Safety. Supplement [1975, 4:174-179]
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Transformation and fate of the chemical after entry into the body of living organisms to decide its bioaccumulation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- disodium4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- IUPAC Name:
- disodium4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- Reference substance name:
- Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- EC Number:
- 240-245-2
- EC Name:
- Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- Cas Number:
- 16090-02-1
- Molecular formula:
- C40H38N12Na2O8S2
- IUPAC Name:
- disodium 5-{[4-(morpholin-4-yl)-6-(phenylamino)-1,3,5-triazin-2-yl]amino}-2-[(E)-2-(4-{[4-(morpholin-4-yl)-6-(phenylamino)-1,3,5-triazin-2-yl]amino}-2-sulfonatophenyl)ethenyl]benzene-1-sulfonate
- Details on test material:
- - Name of test material: disodium4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]stilbene-2,2'-disulphonate
- Molecular formula: C40-H40-N12-O8-S2.2Na
- Molecular weight: 925
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- SIV 50
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- The behaviour of water-soluble fluorescent whitening agents (FWA) was studied in rats and bean plants using 14C-labelled compounds.
- Duration and frequency of treatment / exposure:
- 96 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5 mg/kg
- No. of animals per sex per dose / concentration:
- 4
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- No significant amounts of whitener were absorbed from the digestive tract of the rats.
- Type:
- distribution
- Results:
- No radioactive residues were found in blood, liver, kidney, brain, muscle, or fat 96 hours after dosing with the chemical.
- Type:
- metabolism
- Results:
- Details not available.
- Type:
- excretion
- Results:
- Following oral doses of 5 mg/kg of each of theFWAs to rats, rapid and complete excretion of radioactive material was observed, with an excretion half-life ranging from 7-13 hours.
- Type:
- excretion
- Results:
- Faeces were practically the only route of excretion, indicating, in combination with the short half life times, that no significant amounts of whitener were absorbed from the digestive tract.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not applicable since the chemical does not have pharma application.
Metabolite characterisation studies
- Metabolites identified:
- no
Any other information on results incl. tables
Organs exhibiting radioactivity: No radioactive residues were found in blood, liver, kidney, brain, muscle, or fat.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
From the available information on absorption, distribution and excretion of the chemical Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]- stilbene-2,2'-disulfonate [14C-labelled Fluorescent whitening agent (FWA)] shall have low bio-accumulation potential. - Executive summary:
From the available information on absorption, distribution and excretion of the chemicalDisodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)amino]- stilbene-2,2'-disulfonate [14C-labelled Fluorescent whitening agent (FWA)]shall have low bio-accumulation potential.
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