Registration Dossier
Registration Dossier
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EC number: 201-114-5 | CAS number: 78-40-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: artificial skin model - validity for human skin not evident
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Chemical structure and skin penetrating capacity of a short series of organic phosphates and phosphoric acid
- Author:
- Marzulli F, Callahan JF, Brown DWC
- Year:
- 1 965
- Bibliographic source:
- J Invest Derm, 44, 339-344
- Reference Type:
- publication
- Title:
- Die Durchlaessigkeit der Haut fuer ausgewaehlte aliphatische und alicyclische Traegersubstanzen
- Author:
- Meyer F, Meyer E, Kerk L
- Year:
- 1 959
- Bibliographic source:
- Arzneim Forsch 9, 430-432 (1959) cited in BUA report no 37
- Reference Type:
- review article or handbook
- Title:
- Triethylphosphat BUA Stoffbericht 37 (Maerz 1989)
- Year:
- 1 989
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA) d. Ges. Dt. Chemiker, Weinheim, Basel (Schweiz), Cambridge, New York, NY: VCH 1989 (Bua Stoffbericht 37)
Materials and methods
- Principles of method if other than guideline:
- The skin penetrating capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used
- GLP compliance:
- no
Test material
- Reference substance name:
- Triethyl phosphate
- EC Number:
- 201-114-5
- EC Name:
- Triethyl phosphate
- Cas Number:
- 78-40-0
- Molecular formula:
- C6H15O4P
- IUPAC Name:
- triethyl phosphate
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 32P labeled compound were used
Test animals
- Species:
- other: not applicable - in vitro method was used
- Strain:
- other: not applicable - in vitro method was used
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per group:
- not applicable - in vitro method was used
- Control animals:
- no
Results and discussion
- Conversion factor human vs. animal skin:
- no data
Any other information on results incl. tables
The average maximum steady-state rate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.
Applicant's summary and conclusion
- Executive summary:
The skin penetranting capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used.
The average maximum steady-state rate for triethyl phosphate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.
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