Registration Dossier
Registration Dossier
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EC number: 201-114-5 | CAS number: 78-40-0
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: insufficient documented
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term intraperitoneal toxicity tests
- Author:
- Fassett DW, Roundabush RL
- Year:
- 1 952
- Bibliographic source:
- Arch Ind Hyg Occup Med 6, 525-529 (1952)
Materials and methods
- Principles of method if other than guideline:
- Triethyl phosphate was injected intraperitoneally in rats of 80 to 100 g body weight 5 days a week for four to six weeks. Ten or 20% concentrations were often used.. Dosage was 400 mg/kg bw (ca. half of LD50).
- GLP compliance:
- no
Test material
- Reference substance name:
- Triethyl phosphate
- EC Number:
- 201-114-5
- EC Name:
- Triethyl phosphate
- Cas Number:
- 78-40-0
- Molecular formula:
- C6H15O4P
- IUPAC Name:
- triethyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: intraperitoneal application
- Vehicle:
- propylene glycol
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 to 6 weeks
- Frequency of treatment:
- daily (5 days per week)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400 mg/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent vehicle
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No influence on body weight gain was observed. No hemorrhagic tendency of triethyl phosphate.
Applicant's summary and conclusion
- Executive summary:
Triethyl phosphate was injected intraperitoneally in rats of 80 to 100 g body weight 5 days a week for four to six weeks. Ten or 20% concentrations were often used.. Dosage was 400 mg/kg bw (ca. half of LD50). The body weight gain was determined. No mortality was reported. No influence on body weight gain was observed. No hemorrhagic tendency of triethyl phosphate.
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