Registration Dossier
Registration Dossier
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EC number: 201-114-5 | CAS number: 78-40-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: insufficient documented
Data source
Reference
- Reference Type:
- publication
- Title:
- The metabolism of tri-alkyl phosphates
- Author:
- Jones AR
- Year:
- 1 970
- Bibliographic source:
- Experimentia 26, 492
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- urine of rats and mice were examined for metabolites of 32P-triethylphosphate
- GLP compliance:
- no
Test material
- Reference substance name:
- Triethyl phosphate
- EC Number:
- 201-114-5
- EC Name:
- Triethyl phosphate
- Cas Number:
- 78-40-0
- Molecular formula:
- C6H15O4P
- IUPAC Name:
- triethyl phosphate
- Details on test material:
- no further data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 32P-triethylphosphate
Test animals
- Species:
- other: rats and mice
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral or intraperitoneal administration
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 100 mg/kg bw (oral) or 1000 mg/kg bw (intraperitoneal)
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- no data
- Details on excretion:
- 32P-TEP is rapidly excreted as their metabolites by both rat and mouse with 90% recovery of radioactive material in urine within 16 h and nearly complete recovery over 96 h
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found.
Any other information on results incl. tables
The loss of the alkyl group in trialkyl phosphates is due both to enzymic hydrolysis (P-O cleavage) and de-O-alkylation (C-O cleavage), the latter being known to involve reduced gluthatione as acceptor.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
32P-TEP is rapidly excreted as their metabolites by both rat and mouse with 90% recovery of radioactive material in urine within 16 h and nearly complete recovery over 96 h. Urine of rats and mice were examined for metabolites of 32P-triethylphosphate. 32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found. In neither case was the trialkyl-phosphate excreted unchanged.
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