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EC number: 230-785-7 | CAS number: 7320-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16/06/1988 to 30/06/1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FMC Non-Definitive Dermal Toxicity Protocol (Number 7)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- see any additional information on methods.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrapotassium pyrophosphate
- EC Number:
- 230-785-7
- EC Name:
- Tetrapotassium pyrophosphate
- Cas Number:
- 7320-34-5
- Molecular formula:
- H4O7P2.4K
- IUPAC Name:
- tetrapotassium diphosphate
- Details on test material:
- - Name of test material (as cited in study report): Tetrapotassium pyrophosphate
- Substance type: White solid
- Physical state: solid
- Analytical purity: data on file with sponsor
- Reference No.: 600A-5072X
- Stability under test conditions: data on file with sponsor
- Storage condition of test material: Room temperature
- Other:
FMC-T#: 636
Date received: 03/05/1988
Formulation: Technical
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Animals, Inc., Denver, Pennsylvania on May 18, 1988
- Age at study initiation: Young
- Weight at study initiation: 2.21 - 2.74 kg
- Housing: individually housed in stainless steel cages. DAGB cageboard bedding was used in the litter pans.
- Diet (e.g. ad libitum): ad libitum; Purina High Fiber Rabbit Chow 5326
- Water (e.g. ad libitum): ad libitum; fresh tap water
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 67 - 74°F
- Humidity (%): 52 - 69 %
- Photoperiod (hrs dark / hrs light): 12 hour fluorescent light: 12 hour dark cycle.
IN-LIFE DATES: May 18, 1988 - 13/06/1988
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
The test material was weighed out onto a 4" by 4" 8-ply gauze pad. The gauze was held in place with hypoallergenic tape. The test site was occluded with impervious plastic sheeting. Immediately after dosing each animal was fitted with an everted plastic Elizabethan collar. The collars remained in place until termination of the study.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hour after exposure the wrapping was removed. The test site was wiped cleaned with a gauze moistened with methanol and then rinsed with tap water.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Please see additional information on materials and methods.
- Constant volume or concentration used: yes
- For solids, paste formed: no
VEHICLE
- The test material was moistened with physiological saline. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6: 3 female, 3 males each at 2000 mg/kg bw.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14
- Frequency of observations and weighing: The animals were observed for mortality and clinical signs ( local irritation excluded) at approximately 3 hours after dosing and daily thereafter for 14 days. Bodyweights were taken on the day of dosing and again on days 7 and 14. A description of the local irritation was recorded on days 1, 3, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None of the animals died during the study
- Clinical signs:
- other: All animals remained healthy durng the observation period.
- Gross pathology:
- No gross lesions were found.
- Other findings:
- Results for local irritation are reported in Table 2.
Any other information on results incl. tables
Table 1 - Individual bodyweights
Animal # / sex |
Day 0 (kg) |
Dose (g) |
Amount applied (mg/cm2) |
Day 7 (kg) |
Day 14 (kg) |
1 / male |
2.21 |
4.4 |
42.7 |
2.27 |
2.42 |
2 / male |
2.66 |
5.3 |
51.5 |
2.65 |
2.78 |
3 / male |
2.25 |
4.5 |
43.7 |
2.27 |
2.36 |
Mean ± SD |
2.37 ± 0.249 |
|
46.0 ± 4.82 |
2.40 ± 0.219 |
2.52 ± 0.227 |
|
|
|
|
|
|
4 / female |
2.55 |
5.1 |
49.5 |
2.69 |
2.85 |
5 / female |
2.74 |
5.5 |
53.4 |
2.40 |
2.64 |
6 / female |
2.54 |
5.1 |
49.5 |
2.56 |
2.60 |
Mean ± SD |
2.61 ± 0.113 |
|
50.8 ± 2.25 |
2.55 ± 0.145 |
2.70 ± 0.134 |
Table 2 - Local irritation
Animal # / sex |
Day 1 |
Day 3 |
Day 7 |
Day 14 (kg) |
1 / male |
N |
N |
De |
De |
2 / male |
Er |
Er |
Es |
Es, De |
3 / male |
Ed, Ne, Cb |
Ed, Ne, Cb |
Ts, Ne,Cb |
Ne, Es, Ex, Tb, Ts |
|
|
|
|
|
4 / female |
Er |
Er |
Es, Tb |
Es |
5 / female |
Er |
N |
N |
N |
6 / female |
N |
N |
Es, Ts, Tb |
Es, Ex |
N - normal
De - desquamation
Er - Erythema
Ed - Edema
Ne - Necrosis
Cb - Chemcially burned
Ts - Skin thickening
Ex - Exfoliation
Tb - Tissue bleeding
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the test material is approximated to be relatively non-toxic.
In accordance with Regulation (EC) No. 1272/2008 (EU CLP) tetrapotassium pyrophosphate is not considered to be acutely toxic via the dermal route.
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