Registration Dossier
Registration Dossier
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EC number: 232-142-6 | CAS number: 7789-06-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- other: evaluation
- Rationale for reliability incl. deficiencies:
- other: Three evaluations of available reports on respiratory sensitisation and occupational asthma cases.
Data source
Referenceopen allclose all
- Reference Type:
- other: evaluation
- Title:
- Chromium trioxide, sodium chromate, sodium dichomate, ammonium dichromate and potassium dichromate, risk assessment
- Author:
- EU
- Year:
- 2 005
- Bibliographic source:
- European Chemicals Bureau, Institute for Health and Consumer Production
- Reference Type:
- other: evaluation
- Title:
- Toxicity review 21. The toxicity of chromium and inorganic chromium compounds.
- Author:
- Fairhurst, S. and C. A. Minty
- Year:
- 1 989
- Bibliographic source:
- Health and Safety Executive, Merseyside, UK.
- Reference Type:
- other: evaluation
- Title:
- Criteria Document for Hexavalent Chromium.
- Author:
- Cross, H. J., S. P. Faux, et al.
- Year:
- 1 997
- Bibliographic source:
- Commissioned by International Chromium Development Association (ICDA), Paris, France;
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- other: evaluations on available data
- Principles of method if other than guideline:
- Three reliable, independent evaluations examining available data on chromium-induced respiratory sensitisation.
- GLP compliance:
- no
Test material
- Reference substance name:
- chromium (VI)
- IUPAC Name:
- chromium (VI)
- Details on test material:
- Evaluations of reports on chromium(VI).
Constituent 1
Method
- Type of population:
- occupational
Results and discussion
- Results of examinations:
- The evaluations concluded that asthma caused by exposure to chromium(VI) was suggested already in the 19th century.
Case reports and confirmations received in bronchial challenge tests show that Cr(VI) inhalation is likely to cause occupational asthma. It was also mentioned that Cr(VI) sensitised persons may also have reactions after Cr(III) exposure. The EU RAR concluded that based on available data, a no-effect level or exposure-response relationship cannot be determined for induction or elicitation of occupational asthma.
Applicant's summary and conclusion
- Conclusions:
- Case reports and confirmations received in bronchial challenge tests show that Cr(VI) inhalation is likely to cause occupational asthma.Cr(VI) sensitised persons may also have reactions after Cr(III) exposure. The EU RAR concluded that based on available data, a no-effect level or exposure-response relationship cannot be determined for induction or elicitation of occupational asthma.
- Executive summary:
Three reliable, independent evaluations examined available data on chromium-induced respiratory sensitisation (EU 2005, Cross et al 1997, Fairhurst and Minty 1989). The evaluations concluded that asthma caused by exposure to chromium(VI) was suggested already in the 19th century. Case reports and confirmations received in bronchial challenge tests show that Cr(VI) inhalation is likely to cause occupational asthma. It was also mentioned that Cr(VI) sensitised persons may also have reactions after Cr(III) exposure. The EU RAR concluded that based on available data, a no-effect level or exposure-response relationship cannot be determined for induction or elicitation of occupational asthma.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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