Registration Dossier
Registration Dossier
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EC number: 232-142-6 | CAS number: 7789-06-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The genotoxic and carcinogenic activity of chromium derives from Cr(IV), which in physiological solutions exist as chromate-anion. The strontium cation per se has shown mainly negative results on genotoxic activity when readily soluble salts have been tested.
- One poorly reported study has suggested chromosome aberration activity in mouse bone marrow
- There exist clear evidence that solubilised strontium chromate has genotoxic effects.
- The numerous studies on Cr(VI)-compounds have given the evidence that chromium(VI) is genotoxic
- There exist some positive data on experimental germ cell mutagenicity, but not on strontium chromate. These data are not considered to have significant effect on classification due to low bioavailability.
Chromium-induced DNA damage is thought to be the primary mechanism of chromate genotoxicity and mutagenicity, but it is only clearly observed at doses that are also capable of producing cell death. Recently, data has been presented to the EPA’s Cancer Assessment Review Committee (CARC) to support mutagenicity as the initiating step in Cr(VI)-induced carcinogenesis (McCarroll N, Keshava N et al. An evaluation of the mode of action framework for mutagenic carcinogens case study II: Chromium (VI). Environ Mol Mutag 51;2010;89 -111). Structural genetic lesions produced by Cr(VI) include DNA adducts, DNA-strand breaks, DNA–protein crosslinks, oxidized bases, abasic sites, and DNA inter- and intrastrand crosslinks
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Short description of key information:
- There exist clear evidence that solubilised strontium chromate has genotoxic effects.
- The numerous studies on Cr(VI)-compounds have given the evidence that chromium(VI) is genotoxic
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
The genotoxicity tests of Sr-chromate, and the genotoxicity of chromate anion in general, lead to the conclusion that there are good evidence that Sr-chromate should be classified as genotoxic –Muta 2 according to CLP system.
No additional studies on genotoxicity/mutagenicity are needed.
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