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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

A study was carried out similar or equivalent to EU Method C.11 and OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test), specifically following the Umweltbundesamt (UBA) Guidelines: Bewertung wassergefahrdender Stoffe, III Bestimmung der akuten Bakterientoxizitat, Ad-hoc-Arbeidsgruppe I (Obmann Dr. Niemitz), LTwS, Nr. 10, September 1979. 
Nicotinamide was investigated for its ability to inhibit the cell multiplication of the bacteria species Pseudomonas putida. Cultures of Pseudomonas putida bacteria were exposed to concentrations ranging from 3.9 to 8000 mg Nicotinamide per liter. After incubation the extinction values of the bacterial cell suspensions were measured and a toxicity threshold value of Nicotinamide of 4235 mg/L for Pseudomonas putida was determined. The "Bewertungszahl" (Assessment figure or value for bacterial toxicity) is therefore 2.4 (Bewertung wassergefaehrdender Stoffe, 1979).

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
4 235 mg/L

Additional information